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整合素α1抗體
  • 產品貨號：
    BN41778R
  • 中文名稱：
    整合素α1抗體
  • 英文名稱：
    Rabbit anti-Integrin alpha 1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

    備注

  • BN41778R-50ul

    50ul

    ￥1486.00

    交叉反應：Human,Rat(predicted:Mouse,Cow,Horse) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41778R-100ul

    100ul

    ￥2360.00

    交叉反應：Human,Rat(predicted:Mouse,Cow,Horse) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41778R-200ul

    200ul

    ￥3490.00

    交叉反應：Human,Rat(predicted:Mouse,Cow,Horse) 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產品描述

英文名稱Integrin alpha 1
中文名稱整合素α1抗體
別    名CD 49a; CD49a; CD49 antigen-like family member A; CD49a; CD49a antigen; Integrin alpha-1; ITA1_HUMAN; Itga 1; ITGA1; Laminin and collagen receptor; Very late activation protein 1; VLA 1; VLA-1; VLA1


研究領域細胞生物  免疫學  信號轉導  干細胞  細胞骨架  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Rat,  (predicted: Mouse, Cow, Horse, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=1μg /test IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量128kDa
細胞定位細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Integrin alpha 1:1001-1179/1179 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹Integrins are important extracellular matrix (ECM) receptor proteins located on cell surfaces. They are hetrodimers composed of an alpha and a beta transmembrane glycoprotein subunit. Around twenty two different integrins (different alpha/ beta subunit combinations) are found in nature. Integrins are generally present in high concentrations at the cell surface, but, unlike most other cell surface receptors, they bind ligands with very low affinity. Due to their weak individual binding, integrins need to cluster and bind in groups in order to effectively bind the ECM. Integrins bind many different ligands including laminin. Each integrin is made up of a large N terminal extracellular domain that binds the ECM ligand and a small C terminal cytoplasmic domain that mediates interaction with the actin cytoskeleton and signaling function. Alpha 1 integrin along with alpha 2, alpha L and alpha M has a unique inserted domain. Integrin alpha 1 is a receptor for laminin and collagen. The alpha1 subunit is also known as CD49a. CD49a associates with CD29 (beta 1 integrin), to form an alpha1 beta1 heterodimer, identified as the rat homologue to VLA1, which is involved in cellular adhesion to laminin and collagen.

Function:
Integrin alpha-1/beta-1 is a receptor for laminin and collagen. It recognizes the proline-hydroxylated sequence G-F-P-G-E-R in collagen.

Subunit:
Heterodimer of an alpha and a beta subunit. Alpha-1 associates with beta-1. Interacts with RAB21.

Subcellular Location:
Membrane; Single-pass type I membrane protein.

Similarity:
Belongs to the integrin alpha chain family.
Contains 7 FG-GAP repeats.
Contains 1 VWFA domain.

SWISS:
P56199

Gene ID:
3672

Database links:

Entrez Gene: 3672 Human

Entrez Gene: 109700 Mouse

Entrez Gene: 25118 Rat

Omim: 192968 Human

SwissProt: P56199 Human

SwissProt: Q3V3R4 Mouse

SwissProt: P18614 Rat

Unigene: 644352 Human

Unigene: 482186 Mouse

Unigene: 91044 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.