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細胞角蛋白7抗體
  • 產(chǎn)品貨號：
    BN41734R
  • 中文名稱：
    細胞角蛋白7抗體
  • 英文名稱：
    Rabbit anti-CK7 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產(chǎn)品規(guī)格

    售價

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  • BN41734R-50ul

    50ul

    ￥1486.00

    交叉反應：Rat,Mouse,Human 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41734R-100ul

    100ul

    ￥2360.00

    交叉反應：Rat,Mouse,Human 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

  • BN41734R-200ul

    200ul

    ￥3490.00

    交叉反應：Rat,Mouse,Human 推薦應用：WB,IHC-P,IHC-F,IF,Flow-Cyt,ELISA

產(chǎn)品描述

英文名稱CK7
中文名稱細胞角蛋白7抗體
別    名Cytokeratin 7; Cytokeratin-7; CK 7; CK-7; K7; Keratin 7; Keratin,type II cytoskeletal 7; KRT7; SCL; K2C7_HUMAN.  


研究領域腫瘤  信號轉(zhuǎn)導  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Human, Mouse,  (predicted: Rat, )
產(chǎn)品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 Flow-Cyt=0.2μg/Test IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量54kDa
細胞定位細胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from the middle of human CK7:251-350/469 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in human epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40 kDa and 68 kDa and isoelectric pH between 4.9 – 7.8. The individual human cytokeratins are designated 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.

Function:
Blocks interferon-dependent interphase and stimulates DNA synthesis in cells. Involved in the translational regulation of the human papillomavirus type 16 E7 mRNA (HPV16 E7).

Subunit:
Heterotetramer of two type I and two type II keratins. Interacts with eukaryotic translation initiator factor 3 (eIF3) subunit EIF3S10 and with HPV16 E7.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Expressed in cultured epidermal, bronchial and mesothelial cells but absent in colon, ectocervix and liver. Observed throughout the glandular cells in the junction between stomach and esophagus but is absent in the esophagus.

Post-translational modifications:
Arg-20 is dimethylated, probably to asymmetric dimethylarginine.

Similarity:
Belongs to the intermediate filament family.

SWISS:
P08729

Gene ID:
3855

Database links:

Entrez Gene: 3855 Human

Omim: 148059 Human

SwissProt: P08729 Human

Unigene: 411501 Human

Unigene: 670221 Human



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

結(jié)構(gòu)蛋白（Structural Proteins）
CK-7是一種 54KDa 的中間絲蛋白，存在于大多數(shù)正常組織的腺上皮和移行上皮細胞中。 該抗體與多種良/惡性上皮性腫瘤反應。腺癌中的卵巢、乳腺、肺的腺癌呈陽性反應，而胃腸道的腺癌陰性。移行細胞腫瘤、前列腺癌也呈陽性反應。通常認為 CK7是腺癌和移行上皮細胞癌的比較特異性的標志。