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首頁(yè)>>免疫學(xué)>>一抗>>促腎上腺皮質(zhì)激素釋放因子/促腎上皮質(zhì)激素釋放激素抗體
促腎上腺皮質(zhì)激素釋放因子/促腎上皮質(zhì)激素釋放激素抗體
  • 產(chǎn)品貨號(hào):
    BN41530R
  • 中文名稱:
    促腎上腺皮質(zhì)激素釋放因子/促腎上皮質(zhì)激素釋放激素抗體
  • 英文名稱:
    Rabbit anti-CRF Polyclonal antibody
  • 品牌:
    Biorigin
  • 貨號(hào)

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  • BN41530R-50ul

    50ul

    ¥1486.00

    交叉反應(yīng):Human,Mouse,Rat(predicted:Dog,Pig,Rabbit,GuineaPig) 推薦應(yīng)用:IHC-P,IHC-F,IF,ELISA

  • BN41530R-100ul

    100ul

    ¥2360.00

    交叉反應(yīng):Human,Mouse,Rat(predicted:Dog,Pig,Rabbit,GuineaPig) 推薦應(yīng)用:IHC-P,IHC-F,IF,ELISA

  • BN41530R-200ul

    200ul

    ¥3490.00

    交叉反應(yīng):Human,Mouse,Rat(predicted:Dog,Pig,Rabbit,GuineaPig) 推薦應(yīng)用:IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱CRF
中文名稱促腎上腺皮質(zhì)激素釋放因子/促腎上皮質(zhì)激素釋放激素抗體
別    名Corticoliberin; Corticoliberin precursor; Corticotropin releasing factor; Corticotropin releasing hormone; Corticotropin releasing hormone deficiency included; crf; crh; crh deficiency included; corticoliberin preproprotein; CRF_HUMAN; Corticotropin-releasing factor; CRH1; CRH; Corticotropin-releasing hormone.  


研究領(lǐng)域神經(jīng)生物學(xué)  
抗體來(lái)源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Mouse, Rat,  (predicted: Human, Dog, Pig, Rabbit, Guinea Pig, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:200-800 (石蠟切片需做抗原修復(fù))
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量5/22kDa
細(xì)胞定位分泌型蛋白 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CRF:145-185/196 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹This gene encodes a member of the corticotropin-releasing factor family. The encoded preproprotein is proteolytically processed to generate the mature neuropeptide hormone. In response to stress, this hormone is secreted by the paraventricular nucleus (PVN) of the hypothalamus, binds to corticotropin releasing hormone receptors and stimulates the release of adrenocorticotropic hormone from the pituitary gland. Marked reduction in this protein has been observed in association with Alzheimer's disease. Autosomal recessive hypothalamic corticotropin deficiency has multiple and potentially fatal metabolic consequences including hypoglycemia and hepatitis. In addition to production in the hypothalamus, this protein is also synthesized in peripheral tissues, such as T lymphocytes, and is highly expressed in the placenta. In the placenta it is a marker that determines the length of gestation and the timing of parturition and delivery. A rapid increase in circulating levels of the hormone occurs at the onset of parturition, suggesting that, in addition to its metabolic functions, this protein may act as a trigger for parturition. [provided by RefSeq, Nov 2015]

Function:
This hormone from hypothalamus regulates the release of corticotropin from pituitary gland.

Subunit:
Interacts (via C-terminus) with CRFR1 (via N-terminal extracellular domain).

Subcellular Location:
Secreted.

Similarity:
Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.

SWISS:
P06850

Gene ID:
1392

Database links:

Entrez Gene: 1392 Human

Entrez Gene: 12918 Mouse

Entrez Gene: 81648 Rat

Omim: 122560 Human

SwissProt: P06850 Human

SwissProt: Q8CIT0 Mouse

SwissProt: P01143 Rat

Unigene: 75294 Human

Unigene: 290689 Mouse

Unigene: 10349 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.

CRF陽(yáng)性神經(jīng)元的胞體廣泛分布于下丘腦的室旁核、背縫核和藍(lán)斑核,這些區(qū)域也是去甲腎上腺素(NE)神經(jīng)元與5-羥色胺(5-HT)神經(jīng)元密集的區(qū)域。 CRF既具有神經(jīng)遞質(zhì)的性質(zhì)又具有神經(jīng)激素的性質(zhì)。CRF是聯(lián)系神經(jīng)系統(tǒng)與內(nèi)分泌系統(tǒng)的橋梁,在情感障礙疾患如焦慮和抑郁的發(fā)病中發(fā)揮重要作用.

















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