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細胞周期通道和神經細胞分化蛋白1抗體
  • 產品貨號：
    BN41279R
  • 中文名稱：
    細胞周期通道和神經細胞分化蛋白1抗體
  • 英文名稱：
    Rabbit anti-CEND1 Polyclonal antibody
  • 品牌：
    Biorigin

  • 貨號

    產品規(guī)格

    售價

    備注

  • BN41279R-100ul

    100ul

    ￥2360.00

    交叉反應：Mouse,Rat(predicted:Human,Horse) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

  • BN41279R-200ul

    200ul

    ￥3490.00

    交叉反應：Mouse,Rat(predicted:Human,Horse) 推薦應用：WB,IHC-P,IHC-F,IF,ELISA

產品描述

英文名稱CEND1
中文名稱細胞周期通道和神經細胞分化蛋白1抗體
別    名BM88; BM88 antigen; Cell cycle exit and neuronal differentiation 1; Cell cycle exit and neuronal differentiation protein 1; FLJ90066; MGC34326; CEND_HUMAN  
研究領域細胞生物  神經生物學  細胞周期蛋白  細胞分化  細胞類型標志物  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應Mouse, Rat,  (predicted: Human, Horse, )
產品應用WB=1:500-2000 ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量15kDa
細胞定位細胞膜 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CEND1:4-100/149 
亞    型IgG
純化方法affinity purified by Protein A
儲 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產品介紹BM88 is a 149 amino acid protein that belongs to the CEND1 familly. Involved in neuroblastoma cell differentiation, BM88 is a single-pass type IV membrane protein that is neuron specific. It is suggested that BM88 forms a dimer of two identical polypeptides linked by disulfide bridges. BM88 has a central proline-rich region containing four PxxP motifs, which typically bind SRC homology-3 (SH3) domains, as well as a putative C-terminal transmembrane region, and several potential sites for N-glycosylation, myristoylation and phosphorylation. It is also suggested that a novel signaling mechanism exists by which BM88 interferes with calcium release from inositol 1,4,5-trisphosphate-sensitive stores and exerts anti-proliferative and anti-apoptotic functions. BM88 is an important molecular target for HDAC inhibition, and transcription of BM88 is induced by trichostatin-A.

Function:
CEND1 is a neuron-specific protein. The similar protein in pig enhances neuroblastoma cell differentiation in vitro and may be involved in neuronal differentiation in vivo. Multiple pseudogenes have been reported for this gene.

Subunit:
Homodimer

Subcellular Location:
Membrane; Single-pass type IV membrane protein.

Tissue Specificity:
Neuron specific.

Similarity:
Belongs to the CEND1 family.

SWISS:
Q8N111

Gene ID:
51286

Database links:

Entrez Gene: 51286 Human

Entrez Gene: 57754 Mouse

Entrez Gene: 361675 Rat

Omim: 608213 Human

SwissProt: Q8N111 Human

SwissProt: Q9JKC6 Mouse

SwissProt: Q5FVI4 Rat

Unigene: 22140 Human

Unigene: 87027 Mouse

Unigene: 64460 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.














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