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腦發(fā)育調(diào)節(jié)蛋白抗體
  • 產(chǎn)品貨號(hào)：
    BN41172R
  • 中文名稱：
    腦發(fā)育調(diào)節(jié)蛋白抗體
  • 英文名稱：
    Rabbit anti-Drebrin Polyclonal antibody
  • 品牌：
    Biorigin

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  • BN41172R-100ul

    100ul

    ￥2360.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

  • BN41172R-200ul

    200ul

    ￥3490.00

    交叉反應(yīng)：Human,Mouse,Rat(predicted:Chicken,Dog,Pig,Cow,Horse,Rabbit) 推薦應(yīng)用：IHC-P,IHC-F,IF,ELISA

產(chǎn)品描述

英文名稱Drebrin
中文名稱腦發(fā)育調(diào)節(jié)蛋白抗體
別    名D0S117E; DBN 1; DBN1; Developmentally regulated brain protein; Developmentally-regulated brain protein; DKFZp434D064; DREB_HUMAN; Drebrin 1; Drebrin; Drebrin E; Drebrin1; DrebrinE.   
研究領(lǐng)域腫瘤  細(xì)胞生物  神經(jīng)生物學(xué)  信號(hào)轉(zhuǎn)導(dǎo)  細(xì)胞粘附分子  結(jié)合蛋白  血管內(nèi)皮細(xì)胞  細(xì)胞骨架  細(xì)胞外基質(zhì)  
抗體來源Rabbit
克隆類型Polyclonal
交叉反應(yīng)Human, Mouse, Rat,  (predicted: Chicken, Dog, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
分 子 量71kDa
細(xì)胞定位細(xì)胞漿 
性    狀Liquid
濃    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human Drebrin:151-250/651 
亞    型IgG
純化方法affinity purified by Protein A
儲(chǔ) 存 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
PubMedPubMed
產(chǎn)品介紹Drebrin is a major neuronal F-actin binding protein involved in the control of actin dynamics and neuronal morphogenesis. Three major isoforms of drebrin, resulting from alternative splicing of a single gene, have been identified in the brain: the embryonic isoforms designated E1 and E2 and the adult or A isoform (95-120 kDa). An additional truncated form of drebrin A, s-drebrin/A2 (42 kDa), is specifically expressed in the adult brain, but not in non-neuronal tissues. Drebrin is also widely expressed in a variety of cells including epithelial, endothelial, and smooth muscle cells and is associated at cell-cell adhering junction sites.
Drebrin is thought to play a central role in the formation of axons and dendrites during neuronal development and in neuronal plasticity in the adult brain. The expression of each drebrin isoform is regulated throughout distinct phases in neuronal development. The earliest embryonic form E1, is thought to function in migration, while the E2 isoform, which replaces E1 during embryogenesis, is believed to play a role in migration as well as formation of axons and dendrites. Drebrin E2 is present at low levels in the adult brain. The drebrin A isoform, which is only present in mature neurons, is assumed to be involved in synaptic plasticity. Drebrin E2 and A isoforms are targeted to different regions of actin localization. In neurons, the E2 isoform localizes to the submembrane region, while the A isoform is specifically located and evenly distributed throughout the post-synaptic dendritic spine.

Function:
Drebrins might play some role in cell migration, extension of neuronal processes and plasticity of dendrites, respectively.

Subunit:
Contains 1 ADF-H domain.

Subcellular Location:
Cytoplasm.

Tissue Specificity:
Brain neurons. Also found in the heart, placenta, skeletal muscle, kidney and pancreas.

Similarity:
Contains 1 ADF-H domain.

SWISS:
Q16643

Gene ID:
1627

Database links:

Entrez Gene: 505406 Cow

Entrez Gene: 1627 Human

Entrez Gene: 56320 Mouse

Entrez Gene: 100008894 Rabbit

Entrez Gene: 81653 Rat

Omim: 126660 Human

SwissProt: Q16643 Human

SwissProt: Q9QXS6 Mouse

SwissProt: Q07266 Rat

Unigene: 130316 Human

Unigene: 19016 Mouse

Unigene: 11247 Rat



Important Note:
This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications